論文・総説 (英文)
Kamada, H., Emura, K., Yamamoto, R., Kawahara, K.I., Uto, S., Minami, T., Ito, S., Matsumoto, K.-I. and Emiko Okuda-Ashitaka, E.
Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers-Danlos syndrome.
Sci. Rep. 13:18490, 2023.
Okuda-Ashitaka, E. and Matsumoto, K.-I.
Tenascin-X as a causal gene for classical-like Ehlers-Danlos syndrome.
Front. Genet. 14:1107787, 2023 Review
Nakatomi, K., Ueno, H., Ishikawa, Y., Salim, R.C., Mori, Y., Kanemoto, I., Tancharoen, S., Kikuchi, K., Miura, N., Omori, T., Okuda-Ashitaka, E., Matsumura, K., Imaizumi, H., Motomiya, Y., Maruyama, I. and Kawahara, K.I.
TLR4/MD-2 is a receptor for extracellular nucleophosmin 1.
Biomed. Rep. 14:21, 2021.
Okuda-Ashitaka, E., Yuka Kakuchi, Y., Kakumoto, H., Yamanishi, S., Kamada, H., Yoshidu, T., Matsukawa, S., Ogura, N., Uto, S., Minami, T., Ito, S. and Matsumoto, K.-I.
Mechanical allodynia in mice with tenascin-X deficiency associated with Ehlers-Danlos syndrome.
Sci. Rep. 10:6569, 2020.
Harada, M., Minami, T., Ito, S. and Okuda-Ashitaka, E.
Development of a novel photoaffinity probe for labeling nocistatin receptor.
Biochem. Biophys. Res. Commun., 501:514-519, 2018
Kawabata, K., Nishimura, I., Fujiwara, T., Terauchi, S., Minami, T., Ito, S. and Okuda-Ashitaka, E.
Intrathecal administration of low-dose nociceptin/orphanin FQ induces allodynia via c-Jun N-terminal kinase and monocyte chemoattractant protein-1.
Eur. J. Neurosci., 43:1499-1508, 2016
Okamoto, K., Ohashi, M., Ohno, K., Takeuchi, A., Matsuoka, E., Fujisato, K., Minami, T., Ito, S. and Okuda-Ashitaka, E.
Involvement of NIPSNAP1, a neuropeptide nocistatin-interacting protein, in inflammatory pain.
Mol. Pain, 12:1-11, 2016
Okuda-Ashitaka, E. and Ito, S.
Pain regulation induced by nocistatin-targeting molecules: G protein-coupled-receptor and nocistatin-interacting protein.
Nociceptin Opioid (Litwack, G. eds)
Vitam. Horm., 97:147-165, 2015 Review
Okuda-Ashitaka, E. and Ito, S.
Nocistain : milestone of one decade of research.
Molecular understanding of pain and future treatment of chronic pain. (Zhou, M. eds)
Curr. Pharm. Des., 21:868-884, 2015 Review
Tsuda, M., Kaneko, S., Ando, A., Nishimura, T., Okuda-Ashitaka, E., Ito, S., Taomoto, M., Matsumura, M. and Takahashi, K.
Controllable urokinase gene expression in trabecular meshwork cells.
J. Clin. Exp. Ophthalmol. 5:329, 2014
Okuda-Ashitaka, E., Minami, T., Tsubouchi, S., Kiyonari, H., Iwamatsu, A., Noda, T., Handa, H. and Ito, S.
Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission.
J. Biol. Chem., 287:10403-40413, 2012
Kunori, S., Matsumura, S., Okuda-Ashitaka, E., Katano, T., Audoly, A.P., Urade, Y. and Ito, S.
A novel role of prostaglandin E2 in neuropathic pain: blockade of microglialmigration in the spinal cord.
Glia, 59:208-218, 2011
Ohnaka, M., Okuda-Ashitaka, E., Kaneko, S., Ando, A., Maeda, M., Furuta, K., Suzuki, M., Takahashi, K. and Ito, S.
Induction of arginase II mRNA by nitric oxide using in vitro model of gyrate atrophy of choroid and retina.
Invest. Ophthalmol Vis. Sci., 52:1493-1500, 2011
Matsumura, S., Kunori, S., Mabuchi, T., Katano, T., Nakazawa, T., Abe, T., Watanabe, M., Yamamoto, T., Okuda-Ashitaka, E. and Ito, S.
Impairment of CaMKII activation and attenuation of neuropathic pain in mice lacking NR2B phosphorylated at Tyr1472.
Eur. J. Neurosci., 32:798-810, 2010
Matsumura, S., Takagi, K., Okuda-Ashitaka, E., Lu, J., Naritsuka, H., Yamaguchi, M. and Ito, S.
Characterization of nestin expression in the spinal cord of GFP transgenic mice after peripheral nerve injury.
Neuroscience, 170:942-953, 2010
Lu, J., Katano, T., Okuda-Ashitaka, E., Oishi, Y., Urade, Y. and Ito, S.
Involvement of S-nitrosylation of actin in inhibition of neurotransmitter release by nitric oxide.
Mol. Pain, 5. 58-70, 2009
Katano, T., Furue, H., Okuda-Ashitaka, E., Tagaya, M., Watanabe, M., Yoshimura, M. and Ito, S.
N-Ethylmaleimide-sensitive fusion protein (NSF) is involved in central sensitization in the spinal cord through GluR2 subunit composition switch after inflammation.
Eur. J. Neurosci., 27:3161-3170, 2008
Takagi, K., Okuda-Ashitaka, E., Mabuchi, T., Katano, T., Ohnishi, T., Matsumura, S., Ohnaka, M., Kaneko, S., Abe, T., Hirata, T., Fujiwara, S., Minami, T. and Ito, S.
Involvement of stem cell factor and its receptor tyrosine kinase c-kit in pain regulation.
Neuroscience, 153:1278-1288, 2008
Ohnishi, T., Okuda-Ashitaka, E., Matsumura, S., Katano, T., Nishizawa, M. and Ito, S.
Characterization of signaling pathway for the translocation of neuronal nitric oxide synthase to the plasma membrane by PACAP.
J. Neurochem., 105:2271-2285, 2008
Moriuchi, H., Koda, N., Okuda-Ashitaka, E., Daiyasu, H., Ogasawara, K., Toh, H., Ito, S., Woodward, D.F. and Watanabe, K.
Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily.
J. Biol. Chem., 283:792-801, 2008
Xu, L., Mabuchi, T., Katano, T., Matsumura, S., Okuda-Ashitaka, E., Sakimura, K., Mishina, M. and Ito S.
Nitric oxide (NO) serves as a retrograde messenger to activate neuronal NO synthase in the spinal cord via NMDA receptors.
Nitric Oxide, 17:18-24, 2007
Takagi, K., Matsumura, S., Okuda-Ashitaka, E., Okuda, K., Watanabe, J., Takahashi, H., Iwakura, Y. and Ito, S.
Interleukin-1 is not essential for expression of inducible NOS in hepatocytes induced by lipopolysaccharide in vivo.
Nitric Oxide, 16:433-441, 2007
Kaneko, S., Okuda-Ashitaka, E., Ando, A., Nishimura, K., Igarashi, K., Maeda, M., Furuta, K., Suzuki, M., Matsumura, M. and Ito S.
Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells.
Am. J. Physiol. Cell Physiol., 293:C729-737, 2007
Xu, L., Okuda-Ashitaka, E., Matsumura, S., Mabuchi, T., Okamoto, S., Sakimura, K., Mishina, M. and Ito, S.
Signal pathways coupled to activation of neuronal nitric oxide synthase in the spinal cord by nociceptin/orphanin FQ. Neuropharmacology, 52:1318-1325, 2007
Kaneko, S., Ando, A., Okuda-Ashitaka, E., Maeda, M., Furuta, K., Suzuki, M., Matsumura, M. and Ito, S.
Ornithine transport via cationic amino acid transportor-1is involved in ornithine cytotoxicity in retinal pigment epithelial cells.
Invest. Ophthalmol Vis. Sci., 48:464-471, 2007
Kaneko, S., Ueda-Yamada, M., Ando, A., Matsumura, S., Okuda-Ashitaka, E., Matsumura, M., Uyama, M. and Ito, S.
Cytotoxicity of spermine on retinal pigment epithelial cells.
Invest. Ophthalmol Vis. Sci., 48:455-463, 2007
Katano, T., Mabuchi, T., Okuda-Ashitaka. E., Inagali, N., Kinumi, T. and Ito, S.
Proteomic identification of a novel isoform of collapsing response mediator protein-2 in spinal nerves peripheral to dorsal root ganglia.
Proteomics, 6:6085-6094, 2006
Okuda-Ashitaka, E., Minami, T., Matsumura, S., Takeshima, H., Reinscheid, R. K., Civelli, O. and Ito, S.
The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E2-induced allodynia, tactile pain associated with nerve injury.
Eur. J. Neurosci., 23:995-1004, 2006
Matsumura, S., Abe, T., Mabuchi, T., Katano, T., Takagi, K., Okuda-Ashitaka, E., Tatumi, S., Nakai, Y., Sasaki, Y., Minami, T. and Ito, S.
Rho-kinase mediates spinal nitric oxide formation by prostaglandin E2 via EP3 subtype.
Biochem. Biophys. Res. Commun., 338:550-557, 2005
Ando, A., Yamazaki, Y., Kaneko, S., Miyake, M., Nambu, R., Taomoto, M., Unezaki, S., Okuda-Ashitaka, E., Okumura, T., Ito, S. and Matsumura, M.
Cytoprotection by nipradiol, an anti-glaucomatous agent, via down-regulatoion of apoptosis related gene expression and activation of NF-kB.
Exp. Eye Res., 80:501-507, 2005
Mabuchi, T., Shintani, N., Matsumura, S., Okuda-Ashitaka, E., Hashimoto, H., Muratani, T., Minami, T., Baba, A. and Ito, S.
Pituitary adenylate cyclase-activating polypeptide is required for the development of spinal sensitization and induction of neuropathic pain.
J. Neurosci., 24:7283-7291, 2004
Unezaki, S., Nishizawa, M., Okuda-Ashitaka, E., Masu, Y., Mukai, M., Kobayashi, S., Sawamoto, K., Okano, H. and Ito, S.
Characterization of the isoforms of MOVO zinc finger protein, a mouse homologue of Drosophila Ovo, as transcription factor.
Gene, 336:47-58, 2004
Otsuji, T., Okuda-Ashitaka, E., Kojima, S., Akiyama, H., Ito, S. and Ohmiya, Y.
Monitoring for dynamic biological processing by intra-molecular bioluminescence resonance energy transfer system using secreted luciferase.
Anal. Biochem., 329:230-2378, 2004
Mabuchi,T., Matsumura, S., Okuda-Ashitaka, E., Kitano, T., Kojima, H., Nagano, T.,Minami, T. and Ito, S.
Attenuation of neuropathic pain by nociceptin/orphanin FQ antagonist JTC-801 is mediated by inhibition of nitric oxide production.
Eur. J. Neurosci., 17:1384-1392, 2003
Zeilhofofer, H. U., Reinscheid, R. K., and Okuda-Ashitaka, E.
Nociceptin, Nocistatin and Pain.
Proceeding of the 10th World Congress on Pain, Progress in Pain Reserch and Management, vol. 24, pp.469-480
(in Jonathan O.Dostrovsky, Daniel B. Carr, and Martin Koltzenburg) IASP Press, Seattle, 2003
Muratani, T., Minami, T., Enomoto, U., Sakai, M., Okuda-Ashitaka, E., Kiyokane, K., Mori, H. and Ito, S.
Characterization of nociceptin/orphanin FQ-induced pain responses by the novel receptor antagonist JTC-801.
J. Pharmacol. Exp. Ther., 303:424-430, 2002
Okuda-Ashitaka, E., Minami, T. and Ito, S.
Pain transmission regulated by novel neuropeptides nocistatin and nociceptin/orphanin FQ.
J. Biol. Macromol., 2:3-10, 2002 Review
Minami, T., Matsumura, S., Okuda-Ashitaka, E., Shimamoto, K., Sakimura, K., Mishina, M., Mori, H. and Ito, S.
Characterization of the glutamatergic system for induction and maintenance of allodynia.
Brain Res., 895:178-185, 2001
Ito, S., Okuda-Ashitaka, E. and Minam, T.
Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin.
Neurosci. Res., 41:299-332, 2001 Review
Minam, T., Okuda-Ashitaka, E., Mori, H., Sakimura, K., Watanabe, M., Mishina, M. and Ito, S.
Characterization of nociceptin/orphanin FQ-induced pain responses in conscious mice: neonatal capsaicin treatment and NMDA receptor e subunit knockout mice.
Neuroscience, 97:133-142, 2000
Nakano, H., Minami, T., Abe, K., Arai, T., Tokumura, M., Ibii, N., Okuda-Ashitaka, E., Mori, H. and Ito, S.
Effect of intrathecal nocistatin on the formalin-induced pain in mice versus that of nociceptin/orphanin FQ.
J. Pharmacol. Exp. Ther., 292:331-336, 2000
Okuda-Ashitaka, E. and Ito, S.
Nocistatin: a novel neuropeptide encoded by the gene for the nociceptin/orphanin FQ precursor.
Peptides, 21:1101-1109, 2000 Review
Suzuki-Yamamoto, T., Nishizawa, M., Fukui, M., Okuda-Ashitaka, E., Nakajima, T., Ito, S. and Watanabe, K.
cDNA cloning, expression and charcterization of human prostaglandin F synthase.
FEBS lett., 462:355-340, 1999
Ikeda, S., Okuda-Ashitaka, E., Masu, Y., Suzuki, T., Watanabe, K., Nakao, M., Shingu, K. and Ito, S.
Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.
FEBS lett., 459:433-437, 1999
Minami, T., Okuda-Ashitaka, E., Hori, Y., Sakuma, S., Sugimoto, T., Sakimura, K., Mishina, M. and Ito, S.
Involvement of primary afferent C-fibres in touch-evoked pain (allodynia) induced by prostaglandin E2.
Eur. J. Neurosci., 11:1849-1856, 1999
Lee, T-L., Fung, F. M. Y., Chen, F-G., Chou, N., Okuda-Ashitaka, E., Ito, S., Nishiuchi, Y., Kimura, T. and Tachibana, S.
Identification of human, rat and mouse nocistatin in brain and human cerebrospinal fluid.
NeuroReport, 10:1537-1341, 1999
Okuda-Ashitaka, E., Minami. T., Tachibana, S., Yoshihara, Y., Nishiuchi,Y., Kimura,T. and Ito, S.
Strucutre-activity relationships of nocistatin: a novel peptide blocking nociceptin-induced hyperalgesia and allodynia.
Peptide 1998, Proceeding of the 25th European Peptide Symposium, pp.736-737, (in Bajusz, S. and Hudecz, F. eds) Akademiai Kiado, Budapest,1999
Okuda-Ashitaka, E., Minami. T., Tachibana, S., Yoshihara, Y., Nishiuchi,Y., Kimura,T. and Ito, S.
Strucutre-activity relationships of nocistatin: a novel peptide blocking nociceptin action in pain transmission.
Peptide science 1998, Proceeding of the 35th Japan Peptide Symposium, pp.209-212 (in Kondo, M. ed)
Protein Research Foundation, Osaka, 1999
Nicol, B., Lambert, D. G., Rowbotham, D. J., Okuda-Ashitaka, E., Ito, S., Smart, D. and McKnight, A. T.
Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices.
Eur. J. Pharmacol., 356:R1-R3, 1998
Minami, T., Okuda-Ashitaka, E., Nishiuchi, Y., Kimura, T., Tachibana, S., Mori, H. and Ito, S.
Anti-nociceptive responses produced by human putative counterpart of nocistatin.
Br. J. Pharmacol., 124:1016-1018, 1998
Masu, Y., Ikeda, S., Okuda-Ashitaka, E., Sato, E. and Ito, S.
Expression of murine novel zinc finger proteins highly homologous to Drosophila ovo gene product in testis.
FEBS lett., 421:224-228, 1998
Okuda-Ashitaka, E., Minami, T., Tachibana, S., Yoshihara, Y., Nishiuchi, Y., Kimura, T. and Ito, S.
Nocistatin, a peptide that blocks nociceptin action in pain transmission.
Nature, 392:286-289, 1998
Minami, T., Okuda-Ashitaka, E., Nishizawa, M., Mori, H. and Ito, S.
Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2.
Br. J. Pharmacol., 122:605-610, 1997
Hara,N., Minami, T., Okuda-Ashitaka, E., Sugimoto, T., Sakai, M., Onaka, M., Mori, H., Imanishi, T., Shingu, K. and Ito, S.
Characterization of nociceptin, a novel opioid peptide, for pain transmission in conscious mice.
Br. J. Pharmacol., 121:401-408, 1997
Ezashi, T., Sakamoto, K., Miwa, K., Okuda-Ashitaka, E., Ito, S. and Hayaishi, O.
Genomic organization and characterization of the bovine prostaglandin F2aαreceptor gene.
Gene, 190:271-278, 1997
Okuda-Ashitaka, E., Tachibana, S., Houtani, T., Minami, T., Masu, Y., Nishi, M., Takeshima, H., Sugimoto, T. and Ito, S.
Identification and characterization of an endogenous ligand for opioid receptor homologue ROR-C: its involvement in allodynic response to innocuous stimulus.
Mol. Brain. Res., 43:96-104, 1996
Minami, T., Okuda-Ashitaka, E., Mori, H., Ito, S. and Hayaishi, O.
Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice.
J. Pharmacol. Exp. Ther., 278:1146-1152, 1996
Okuda-Ashitaka, E., Sakamoto, K., Ezashi, T., Miwa K., Ito, S. and Hayaishi, O.
Suppression of prostaglandin E receptor signaling by the variant form of EP1 subtype.
J.Biol. Chem., 271:31255-31261, 1996
Minami, T., Onaka, M., Mori, H., Okuda-Ashitaka, E., Ito, S. and Hayaishi, O.
L-NAME, an inhibitor of nitric oxide synthase, blocks the established allodynia induced by intrathecal administration of prostaglandin E2.
Neurosci. Lett., 201:239-242, 1995
Sakamoto, K., Ezashi, T., Miwa, K., Okuda-Ashitaka, E., Houtani, T., Sugimoto, T., Ito, S. and Hayaishi, O.
Molecular cloning and expression of a cDNA of the bovine prostaglandin F2α receptor.
Advances in Prostaglandin, Thromboxane, Leukotriene Res. 23:259-261, 1995
Sakamoto, K., Miwa, K., Ezashi, T., Okuda-Ashitaka, E., Okuda, K., Houtani, T., Sugimoto, T., Ito, S. and Hayaishi, O.
Expression of mRNA encoding the prostaglandin F2a receptor in the bovine corpora lutea throughout the oestrous cycle and pregnancy.
J. Reprod. Fertil., 103:99-105, 1994
Ito, S., Sakamoto, K., Mochizuki-Oda, N., Ezashi, T., Miwa, K., Okuda-Ashitaka, E., Shevchenko, V. I., Kiso, Y. and Hayaishi, O. Prostaglandin F2a receptor is coupled to Gq in cDNA-transfected Chinese hamster ovary cells.
Biochem. Biophys. Res. Commun., 200:756-762, 1994
Sakamoto, K., Ezashi, T., Miwa, K., Okuda-Ashitaka, E., Houtani, T., Sugimoto, T., Ito, S. and Hayaishi, O.
Molecular cloning and expression of a cDNA of the bovine prostaglandin F2a receptor.
J. Biol. Chem., 269:3881-3856, 1994
Okuda-Ashitaka, E., Sakamoto, K., Giles, H., Ito, S. and Hayaishi, O.
Cyclic-AMP-dependent Ca2+ influx elicited by prostaglandin D2 in freshly isolated nonchromaffin cells from bovine adrenal medulla.
Biochim. Biophys. Acta., 1176:148-154, 1993
Oda, K., Fujitani, F., Watanabe, T., Inui, T., Okada, T., Urade, Y.,Okuda-Ashitaka, E. and Ito, S.
Endothelin stimulates both cAMP formation and phosphatidylinositol hydrolysis in cultured embryonic bovine tracheal cells.
FEBS Lett., 299:187-191, 1992
Ito, S., Negishi, M., Sugama, K., Okuda-Ashitaka, E. and Hayaishi, O.
Signal transduction coupled to prostaglandin D2.
Advances in Prostaglandin, Thromboxane, Leukotriene Res. 21:71-74, 1990
Okuda-Ashitaka, E., Negishi, M., Sugama, K., Hatanaka, M. and Ito, S.
Cyclic AMP-mediated inhibition of cell growth by prostaglandin D2 in a fibroblastic cell line (EBTr).
Eicosanoids, 3: 213-218, 1990
Ito, S., Okuda, E., Sugama, K., Negishi, M. and Hayaishi, O.
Evaluation of ZK110841 and AH6809, an agonist and an antagnist of prostaglandin DP-receptors on human platelets, with a PGD2-responsive cell line from bovine embryonic trachea.
Br. J. Pharmacol., 99:13-14, 1990
総説・著書(和文)
近江谷克裕, 芦高恵美子, 吉宗一晃
カラー コア生化学 (翻訳:Biochemistry, Molecular Biology, and Genetics)
2018.7.2. 西村書店
芦高恵美子
糖尿病性神経因性疼痛の分子メカニズム
Bio Clinica 32:75-77, 2017
芦高恵美子, 伊藤誠二.
III. 各種疾患 11.機能性疾患 1)ノシセプチンとノシスタチン.
Annual Review 神経 2014, 272-279, 2014 中外医学社
芦高恵美子, 伊藤誠二.
神経ペプチドUpdate 痛み ノシセプチンとノシスタチン.
Clinical Neuroscience 30:148-151, 2012
芦高恵美子.
脊髄の疼痛発症におけるシナプス制御.
生化学 84:1019-1023, 2012
芦高恵美子.
アロディニア.
生化学 84:1031, 2012
芦高恵美子.
第3章 その他の慢性疼痛のメカニズムと治療のアプローチ 第1節 遺伝子的要因による痛み発現メカニズム.
慢性疼痛における薬剤選定と治療薬開発 124-130, 2010, 技術情報協会
松村伸治, 阿部哲也, 芦高恵美子, 伊藤誠二.
痛みのメカニズムとその制御、痛みにおけるNOの関与.
Bio Clinica 23:397-403, 2008
芦高恵美子, 阿部哲也, 松村伸治, 伊藤誠二.
脊髄後角におけるNMDA受容体リン酸化と神経因性疼痛.
慢性疼痛、vol.26、pp.41-47、2007
南敏明, 芦高恵美子, 伊藤誠二.
プロスタグランジンとノシセプチン.
麻酔 56:S172-S178, 2007.
芦高恵美子, 南敏明, 伊藤誠二.
脊髄におけるノシセプチン/オーファニンFQを介したプロスタグランジンによる疼痛制御ネットワーク.
ペインクリニック 27:547-559, 2006
芦高恵美子, 伊藤誠二
痛みシグナルの制御機構と最新治療エビデンス -ノシセプチンの疼痛制御-
医学のあゆみ 211:375-379, 2004
芦高恵美子, 伊藤誠二
ノシセプチン
痛み -基礎・診断・治療- (編集 花岡一雄), 37-40, 2003, 朝倉書店
伊藤誠二, 芦高恵美子, 南敏明.
ノシセプチンとノシスタチンの痛覚調節機構.
痛みの基礎と臨床(編集 緒方宣邦、柿木隆介),115-127, 2003, 真興交易医書出版部
南敏明, 中野弘行, 芦高恵美子, 森秀磨, 伊藤誠二.
遺伝子欠損マウスを用いての疼痛制御機構の研究 ④アロディニアにおけるプロスタグランジンおよびオピオイドの関与.
オピオイドの基礎と臨床 (編集 鎮痛薬・オピオイド研究会), 199-207、2000、エルセビア・サイエンスミクス
伊藤誠二, 芦高恵美子, 南敏明.
痛みの最前線 ノシセプチン関連 ①ノシスタチンの鎮痛作用.
オピオイド治療 課題と新潮流 (編集 鎮痛薬・オピオイド研究会), 260-267, 2000, エルセビア・サイエンスミクス
伊藤誠二, 芦高恵美子, 西澤幹雄, 南敏明.
痛みの分子機構と医学への応用.
実験医学 18:2332-2337,2000
芦高恵美子, 伊藤誠二.
新規痛覚制御ペプチド・ノシスタチン.
脳の科学 21:655-659, 1999
芦高恵美子, 伊藤誠二.
痛みの制御 -ノシセプチンとノシスタチン-.
実験医学16:1561-1564, 1998
芦高恵美子, 伊藤誠二
ノシセプチンとノシスタチン:痛みの制御をめぐって.
Bio Clinica13:970-974, 1998
三輪直人, 奥田恵美子.
第5巻 脳と神経 神経培養細胞
1)講座プロスタグランジン(編集 早石修, 室田誠逸, 山本尚三)9:145-158, 1987 東京化学同人